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CHEM21 Publications

  1. R. Kapdi, A. C. Whitwood, Williamson, J. M. Lynam, M. J. Burns, Williams, A. J. Reay, J. Holmes and I. J. S. Fairlamb, The elusive structure of Pd2(dba)3. Examination by isotopic labeling, NMR spectroscopy, and X-ray diffraction analysis: synthesis and characterization of Pd2(dba-Z)3 complexes, J. Am. Chem. Soc., 2013, 135, 8388–8399.
  2. Maes, T. R. M. Rauws and B. U. W. Maes, Synthesis of C8N9 Annulated Purines by Iron-Catalyzed CH Amination, Chem. Eur. J., 2013, 19, 9137–9141.
  3. Schranck, A. Tlili, H. Alsabeh Pamela G and Neumann, M. Stradiotto and M. Beller, Palladium-catalysed carbonylativealpha-arylation of acetone and acetophenones to 1,3-diketones, Chemistry, 2013, 19, 12624–12628.
  4. Schranck, X.-F. Wu, H. Tlili Anis and Neumann and M. Beller, A novel double carbonylation reaction of aryl halides: selective synthesis of 5-arylfuranones, Chemistry, 2013, 19, 12959–12964.
  5. Vogl, C. Ruth, T. Pitzer Julia and Kickenweiz and A. Glieder, Synthetic core promoters for Pichia pastoris, ACS Synth. Biol., 2014, 3, 188–191.
  6. C. Cioc, E. Ruijter and R. V. A. Orru, Multicomponent reactions: advanced tools for sustainable organic synthesis, Green Chem., 2014, 16, 2958–2975.
  7. T. T. Kumpulainen and A. Pohjakallio, Selective Palladium-Catalyzed Direct C H Arylation of Unsubstituted N-Protected Pyrazoles, Adv. Synth. Catal., 2014, 356, 1555–1561.
  8. Paggiola, A. J. Hunt, J. McElroy Con R and Sherwood and J. H. Clark, Biocatalysis in bio-derived solvents: an improved approach for medium optimisation, Green Chem., 2014, 16, 2107–2110.
  9. Wells and H.-P. Meyer, Biocatalysis as a Strategic Green Technology for the Chemical Industry, ChemCatChem, 2014, 6, 918–920.
  10. N. Scheller, S. Fademrecht, S. Hofelzer, J. Pleiss, N. J. Leipold Friedemann and Turner, B. M. Nestl and B. Hauer, Enzyme toolbox: novel enantiocomplementary imine reductases, Chembiochem, 2014, 15, 2201–2204.
  11. E. Hurst, R. M. Gorman, A. Drouhin Pauline and Perry and R. J. K. Taylor, A direct C-H/Ar-H coupling approach to oxindoles, thio-oxindoles, 3,4-dihydro-1 H-quinolin-2-ones, and 1,2,3,4-tetrahydroquinolines, Chemistry, 2014, 20, 14063–14073.
  12. Prat, J. Hayler and A. Wells, A survey of solvent selection guides, Green Chem., 2014, 16, 4546–4551.
  13. Bechi, S. Herter, C. McKenna Shane and Riley, S. Leimkühler, N. J. Turner and A. J. Carnell, Catalytic bio–chemo and bio–bio tandem oxidation reactions for amide and carboxylic acid synthesis, Green Chem., 2014, 16, 4524–4529.
  14. P. Ashcroft, P. J. Dunn and A. S. Hayler John D and Wells, Survey of Solvent Usage in Papers Published in Organic Process Research & Development 1997–2012, Org. Process Res. Dev., 2015, 19, 740–747.
  15. Debnath, M. Baeten, N. Lefevre, S. Van Daele and B. U. W. Maes, ChemInform Abstract: Synthesis of Secondary Amides from N-Substituted Amidines by Tandem Oxidative Rearrangement and Isocyanate Elimination, ChemInform, 2015, 46.
  16. Harsanyi and G. Sandford, Organofluorine chemistry: applications, sources and sustainability, Green Chem., 2014, 17, 2081–2086.
  17. Schranck, M. Burhardt, Bornschein, H. Neumann, T. Skrydstrup and M. Beller, Palladium-catalyzed carbonylativealpha-arylation to beta-ketonitriles, Chemistry, 2014, 20, 9534–9538.
  18. Geier, P. Fauland, T. Vogl and A. Glieder, Compact multi-enzyme pathways in P. pastoris, Chem. Commun., 2015, 51, 1643–1646.
  19. R. McElroy, A. Constantinou, Jones, L. Summerton and J. H. Clark, Towards a holistic approach to metrics for the 21st century pharmaceutical industry, Green Chem., 2015, 17, 3111–3121.
  20. Tlili, J. Schranck, H. Pospech Jola and Neumann and M. Beller, Ruthenium-Catalyzed Hydroaroylation of Styrenes in Water through Directed CH Bond Activation, ChemCatChem, 2014, 6, 1562–1566.
  21. Hussain, F. Leipold, E. Man Henry and Wells, S. P. France, G. Mulholland Keith R and Grogan and N. J. Turner, An (R)-Imine Reductase Biocatalyst for the Asymmetric Reduction of Cyclic Imines, ChemCatChem, 2015, 7, 579–583.
  22. M. McKenna, S. Leimkühler, Herter, N. J. Turner and A. J. Carnell, Enzyme cascade reactions: synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem, Green Chem., 2015, 17, 3271–3275.
  23. G. Turrini, M. Hall and K. Faber, Enzymatic Synthesis of Optically Active Lactones via Asymmetric Bioreduction using Ene-Reductases from the Old Yellow Enzyme Family, Adv. Synth. Catal., 2015, 357, 1861–1871.
  24. E. Ihanainen, E. T. T. Kumpulainen and A. M. P. Koskinen, Palladium-Catalyzed Direct C–H Arylation of Dicyanobenzenes, Eur. J. Org. Chem., 2015, 2015, 3226–3229.
  25. Harsanyi and G. Sandford, Fluorine gas for life science syntheses: green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters, Green Chem., 2015, 17, 3000–3009.
  26. J. Williams, A. J. Reay and I. J. S. Whitwood Adrian C and Fairlamb, A mild and selective Pd-mediated methodology for the synthesis of highly fluorescent 2-arylated tryptophans and tryptophan-containing peptides: a catalytic role for Pd0 nanoparticles?, Chem. Commun., 2014, 50, 3052–3052.
  27. Herter, S. M. McKenna, S. Frazer Andrew R and Leimkühler, A. J. Carnell and N. J. Turner, Galactose Oxidase Variants for the Oxidation of Amino Alcohols in Enzyme Cascade Synthesis, ChemCatChem, 2015, 7, 2313–2317.
  28. J. S. Fairlamb, Redox-Active NOx Ligands in Palladium-Mediated Processes, Angew. Chem. Int. Ed., 2015, 54, 10415–10427.
  29. Wagschal, J. Guilbaud, V. Rabet Pauline and Farina and S. Lemaire, alpha-C-Glycosides via syn Opening of 1,2-Anhydro Sugars with Organozinc Compounds in Toluene/n-Dibutyl Ether, J. Org. Chem., 2015, 80, 9328–9335.
  30. Loos, H. Alex, J. Hassfeld, Lovis, J. Platzek, N. Steinfeldt and S. Hübner, Selective Hydrogenation of Halogenated Nitroaromatics to Haloanilines in Batch and Flow, Org. Process Res. Dev., 2016, 20, 452–464.
  31. Fesko, G. A. Strohmeier and R. Breinbauer, Expanding the threonine aldolase toolbox for the asymmetric synthesis of tertiaryalpha-amino acids, Appl. Microbiol. Biotechnol., 2015, 99, 9651–9661.
  32. Harsanyi and G. Sandford, 2-Fluoromalonate Esters: Fluoroaliphatic Building Blocks for the Life Sciences, Org. Process Res. Dev., 2014, 18, 981–992.
  33. A. Fisher, A. Harsanyi, D. S. Sandford Graham and Yufit and J. A. K. Howard, Fluorotetrahydroquinolines from diethyl 2-fluoromalonate ester, Chimia, 2014, 68, 425–429.
  34. Harsanyi, G. Sandford and J. A. Yufit Dmitri S and Howard, Syntheses of fluorooxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester, Beilstein J. Org. Chem., 2014, 10, 1213–1219.
  35. Mampuys, Y. Zhu, E. Vlaar Tjøstil and Ruijter, R. V. A. Orru and B. U. W. Maes, Sustainable Three-Component Synthesis of Isothioureas from Isocyanides, Thiosulfonates, and Amines, Angew. Chem. Int. Ed., 2014, 53, 12849–12854.
  36. Weninger, A. Glieder and T. Vogl, A toolbox of endogenous and heterologous nuclear localization sequences for the methylotrophic yeast Pichia pastoris, FEMS Yeast Res., 2015, 15.
  37. Essani, A. Glieder and M. Geier, Combinatorial pathway assembly in yeast, 2015.
  38. P. Kelly, A. Eichler, S. Herter, D. C. Kranz, N. J. Turner and S. L. Flitsch, Active site diversification of P450cam with indole generates catalysts for benzylic oxidation reactions, Beilstein J. Org. Chem., 2015, 11, 1713–1720.
  39. Geier, C. Brandner, G. A. Strohmeier, M. Hall, F. S. Hartner and A. Glieder, Engineering Pichia pastoris for improved NADH regeneration: A novel chassis strain for whole-cell catalysis, Beilstein J. Org. Chem., 2015, 11, 1741–1748.
  40. J. Willis, C. A. Fisher, A. Alder Catherine M and Harsanyi, L. Shukla, J. P. Adams and G. Sandford, Sustainable synthesis of enantiopure fluorolactam derivatives by a selective direct fluorination – amidase strategy, Green Chem., 2016, 18, 1313–1318.
  41. J. Blacker and K. E. Jolley, Continuous formation of N-chloro-N,N-dialkylamine solutions in well-mixed meso-scale flow reactors, Beilstein J. Org. Chem., 2015, 11, 2408–2417.
  42. C. Johnson and S. P. Marsden, A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines, Beilstein J. Org. Chem., 2016, 12, 1–4.
  43. Both, H. Bush, P. P. Kelly, F. G. Mutti, N. J. Turner and S. L. Flitsch, Whole-Cell Biocatalysts for Stereoselective C–H Amination Reactions, Synfacts, 2016, 12, 307–307.
  44. Wiltschi, Protein Building Blocks and the Expansion of the Genetic Code, Synthetic Biology, 2016, 143–209.
  45. S. Wells, J. W. Wong, D. A. Michels Peter C and Entwistle, K. Fandrick, A. Finch Gregory L and Goswami, H. Lee, S. Mix, T. S. Moody, L. Pang, R. K. Sato, Turner and T. J. Watson, Case Studies Illustrating a Science and Risk-Based Approach to Ensuring Drug Quality When Using Enzymes in the Manufacture of Active Pharmaceuticals Ingredients for Oral Dosage Form, Org. Process Res. Dev., 2016, 20, 594–601.
  46. Weninger, A.-M. Hatzl, Schmid, T. Vogl and A. Glieder, Combinatorial optimization of CRISPR/Cas9 expression enables precision genome engineering in the methylotrophic yeast Pichia pastoris, J. Biotechnol., 2016, 235, 139–149.
  47. Vogl, L. Sturmberger, R. Kickenweiz Thomas and Wasmayer, C. Schmid, Hatzl, M. A. Gerstmann, J. Pitzer, M. Wagner, G. G. Thallinger and A. Geier Martina and Glieder, A Toolbox of Diverse Promoters Related to Methanol Utilization: Functionally Verified Parts for Heterologous Pathway Expression in Pichia pastoris, ACS Synth. Biol., 2016, 5, 172–186.
  48. J. Reay and I. J. S. Fairlamb, Catalytic C–H bond functionalisation chemistry: the case for quasi-heterogeneous catalysis, Chem. Commun., 2015, 51, 16289–16307.
  49. Prat, A. Wells, J. Hayler, Sneddon, C. R. McElroy, S. Abou-Shehada and P. J. Dunn, CHEM21 selection guide of classical- and less classical-solvents, Green Chem., 2016, 18, 288–296.
  50. Prat, A. Wells, J. Hayler, Sneddon, C. R. McElroy, S. Abou-Shehada and P. J. Dunn, Correction: CHEM21 selection guide of classical- and less classical-solvents, Green Chem., 2015, 17, 4848–4848.
  51. C. Cioc, H. D. Preschel, G. van der Heijden, E. Ruijter and R. V. A. Orru, Trityl Isocyanide as a Mechanistic Probe in Multicomponent Chemistry: Walking the Line between Ugi- and Strecker-type Reactions, Chemistry, 2016, 22, 7837–7842.
  52. C. Cioc, P. Schuckman, Preschel, T. Vlaar, E. Ruijter and R. V. A. Orru, Brønsted Acid-Catalyzed Cyanotritylation of Aldehydes by Trityl Isocyanide, Org. Lett., 2016, 18, 3562–3565.
  53. Ormerod, N. Lefevre, I. Dorbec Matthieu and Eyskens, P. Vloemans, K. Duyssens, V. Diez de la Torre, N. Kaval, S. Merkul Eugen and Sergeyev and B. U. W. Maes, Potential of Homogeneous Pd Catalyst Separation by Ceramic Membranes. Application to Downstream and Continuous Flow Processes, Org. Process Res. Dev., 2016, 20, 911–920.
  54. Mampuys, Y. Zhu, E. Sergeyev Sergey and Ruijter, R. V. A. Orru, V. Doorslaer and B. U. W. Maes, Iodide-Catalyzed Synthesis of Secondary Thiocarbamates from Isocyanides and Thiosulfonates, Org. Lett., 2016, 18, 2808–2811.
  55. K. Howard, M. Müller and A. Berry Alan and Nelson, An Enantio- and Diastereoselective Chemoenzymatic Synthesis ofalpha-Fluoro beta-Hydroxy Carboxylic Esters, Angew. Chem. Int. Ed Engl., 2016, 55, 6767–6770.
  56. C. Cioc, P. Schuckman, Preschel, T. Vlaar, E. Ruijter and R. V. A. Orru, Brønsted Acid-Catalyzed Cyanotritylation of Aldehydes by Trityl Isocyanide, Org. Lett., 2016, 18, 3562–3565.
  57. J. Reay, L. K. Neumann and I. J. S. Fairlamb, Catalyst Efficacy of Homogeneous and Heterogeneous Palladium Catalysts in the Direct Arylation of Common Heterocycles, Synlett, 2016, 27, 1211–1216.
  58. F. Van Steijvoort, N. Kaval and B. U. W. Kulago Artem A and Maes, Remote Functionalization: Palladium-Catalyzed C5(sp3)-H Arylation of 1-Boc-3-aminopiperidine through the Use of a Bidentate Directing Group, ACS Catal., 2016, 6, 4486–4490.
  59. Maes and B. U. W. Maes, Chapter Five – A Journey Through Metal-Catalyzed CH Functionalization of Heterocycles: Insights and Trends, Advances in Heterocyclic Chemistry, 2016, 120, 137–194.
  60. N. Scheller, M. Lenz, B. Hammer Stephan C and Hauer and B. M. Nestl, Imine Reductase-Catalyzed Intermolecular Reductive Amination of Aldehydes and Ketones, ChemCatChem, 2015, 7, 3239–3242.
  61. Summerton, R. J. Taylor and J. H. Clark, Promoting the uptake of green and sustainable methodologies in pharmaceutical synthesis: CHEM21 education and training initiatives, Sustainable Chemistry and Pharmacy, 2016, 4, 67–76.
  62. Abou-Shehada, P. Mampuys, B. U. W. Maes, Clark and L. Summerton, An evaluation of credentials of a multicomponent reaction for the synthesis of isothioureas through the use of a holistic CHEM21 green metrics toolkit, Green Chem., 2016, 19, 249–258.
  63. van der Heijden, J. Kraakman, Biemolt, E. Ruijter and R. V. A. Orru, Metal-free one-potalpha-carboxylation of primary alcohols, Org. Biomol. Chem., 2016, 14, 9716–9719.
  64. C. Johnson and S. P. Marsden, Precious-Metal-Free Heteroarylation of Azlactones: Direct Synthesis ofalpha-Pyridyl, alpha-Substituted Amino Acid Derivatives, Org. Lett., 2016, 18, 5364–5367.
  65. Sturmberger, T. Chappell, F. Geier Martina and Krainer, K. J. Day, S. Vide Ursa and Trstenjak, A. Schiefer, L. Richardson Toby and Soriaga, B. Darnhofer, R. Birner-Gruenberger, B. S. Glick, I. Tolstorukov, J. Cregg, K. Madden and A. Glieder, Refined Pichia pastoris reference genome sequence, J. Biotechnol., 2016, 235, 121–131.
  66. Bergner, T. Pavkov-Keller, Kreuzer, J. Kowaliuk, M. Plank, K. Runggatscher, N. G. Turrini, S. Zucol Benjamin and Wallner, K. Faber and P. Gruber Karl and Macheroux, Anthranoyl-CoA monooxygenase/reductase from Azoarcus evansii possesses both FMN and FAD in two distinct and independent active sites, Biochim. Biophys. Acta, 2015, 1854, 890–896.
  67. G. Turrini, R. C. Cioc, D. J. H. van der Niet, E. Ruijter, R. V. A. Orru, M. Hall and K. Faber, Biocatalytic access to nonracemicgamma-oxo esters via stereoselective reduction using ene-reductases, Green Chem., 2016.
  68. G. Turrini, E. Eger, Reiter, K. Faber and M. Hall, Sequential Enzymatic Conversion ofalpha-Angelica Lactone to gamma-Valerolactone through Hydride-Independent C=C Bond Isomerization, ChemSusChem, 2016, 9, 3393–3396.
  69. Cano, P. Villuendas, E. P. Benito Ana M and Urriolabeitia and W. K. Maser, Carbon nanotube-supported gold nanoparticles as efficient catalyst for the selective hydrogenation of nitroaromatic derivatives to anilines, Materials Today Communications, 2015, 3, 104–113.
  70. Baramov, P. Loos, J. Hassfeld, H. Alex, M. Beller, T. Stemmler, G. Meier, M. Gottfried and S. Roggan, Encapsulated Cobalt Oxide on Carbon Nanotube Support as Catalyst for Selective Continuous Hydrogenation of the Showcase Substrate 1-Iodo-4-nitrobenzene, Adv. Synth. Catal., 2016, 358, 2903–2911.
Previous
  1. D. C. Montgomery, Design and Analysis of Experiments, John Wiley & Sons, 2008.
  2. R. Bandichhor, A. Bhattacharya, L. Diorazio, P. Dunn, K. Fraunhoffer, F. Gallou, J. Hayler, M. Hickey, W. Hinkley, D. Hughes, L. Humphreys, B. Kaptein, S. Mathew, T. Rammeloo, P. Richardson and T. White, Green Chemistry Articles of Interest to the Pharmaceutical Industry, Organic Process Research & Development, 2013, 17, 615-626.