Metrics can be used to guide reaction discovery to design an effective and inherently green methodology. Highlighting potential issues as early as possible in discovery stage will allow problems to be addressed earlier in the development process. In order to assess the greenness of a reaction or process, quantitative and qualitative metrics should be employed. There are a multitude of metrics available in the literature that can be used to measure, compare and assess methodologies and difficulty often arises when deciding which metrics to use. Rather than viewing one step or substance in isolation, or focussing solely on mass based metrics, it is essential that a holistic viewpoint is taken, considering a full range of issues. This is to ensure that a balance is struck and the best possible outcome for the methodology as a whole is found.
By the end of this module you should: