This page reproduces content from Beyond Mass-based Metrics: Evaluating the Greenness of Your Reaction, in Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, , Royal Society of Chemistry, Cambridge, UK, 2016, ch. 4, pp. 41-53.,
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Metrics will not provide a definitive answer to the question ‘is my reaction green?’ – this is never a straightforward yes or no answer, as there are numerous factors to take into consideration. It should however help to answer probably the most important question, ‘is my reaction greener?’ As with all things, a balance must be struck and a number of considerations should be incorporated into the decision making process.
An approach that encompasses more than mass based metrics has been studied in this module. This, alongside a greater understanding of the issues surrounding sustainability, and the ability to interpret the metrics results, should provide evidence to suggest where improvements could be made, and where methodologies are performing well.
Ultimately, the use of metrics bridges the gap between discovery and larger scale/process chemistry by highlighting issues at an earlier stage.
An evaluation of credentials of a multicomponent reaction for the synthesis of isothioureas through the use of a holistic CHEM21 green metrics toolkit, Green Chem., 2016, 19, 249–258.,
Towards a holistic approach to metrics for the 21st century pharmaceutical industry, Green Chem., 2015, 17, 3111-3121.,
Beyond Mass-based Metrics: Evaluating the Greenness of Your Reaction, in Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, , Royal Society of Chemistry, Cambridge, UK, 2016, ch. 4, pp. 41-53.,
Metrics to ‘green’ chemistry-which are the best?, Green Chem., 2002, 4, 521-527.,
Evaluating the “Greenness” of chemical processes and products in the pharmaceutical industry-a green metrics primer, Chem. Soc. Rev., 2012, 41, 1485-1498.,
Look at the methods again from the first module (c.f. Why are Metrics important?) now we have provided the assessment using the CHEM21 metrics toolkit at 1st pass.
Would you now change your mind about the greenest option?
There is not necessarily a right or wrong answer. But this example shows: