Further Metrics and Key Considerations

Reproduced Content

The video on this page reproduces content from L. Summerton and A. ConstandinouBeyond Mass-based Metrics: Evaluating the Greenness of Your Reaction, in Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, L. Summerton, H. F. Sneddon, L. C. Jones and J. H. Clark, Royal Society of Chemistry, Cambridge, UK, 2016, ch. 4, pp. 41-53.

It is copyright to the Royal Society of Chemistry (RSC) and is reproduced here with their express permission. If you wish to reproduce it elsewhere you must obtain similar permission from the RSC.

In this video Louise Summerton at the Green Chemistry Centre of Excellence, University of York describes a variety of other parameters, aside from efficiency based metrics, that should be taken into consideration when assessing the greenness of a reaction.

Direct amidation exercise (part 2)

In this exercise (attached here) we revisit the direct amidation example looked at earlier, and examine some of the wider considerations to assess the greenness of the reaction (Scheme 1).  You will need to use the data sheet to complete the exercise.

Scheme 1: Direction amidation example reaction

Scheme 1: Direction amidation example reaction[1]

After completing the exercise you can check your answers against the answer sheet.

  1. P. Starkov and T. D. Sheppard, Borate esters as convenient reagents for direct amidation of carboxylic acids and transamidation of primary amides, Organic & Biomolecular Chemistry, 2011, 9, 1320-1323.