A large number of solvent selection guides are available in the literature and have been developed in-house by a number of pharmaceutical companies including GlaxoSmithKline, Pfizer, Sanofi and Astra Zeneca. [1] [2] [3] [4]. The ACS GCI PR has also produced an industry-wide solvent selection guide, which is also available as a free application for mobile phones. The ACS GCI PR has also produced a Solvent Selection Tool which enables the selection of solvents based upon a variety of key properties.
Although there are a number of solvents where strong correlations in classification exist between the different guides, there are a number of discrepancies. The varying needs and priorities of individual businesses will have direct influence over the exact rankings of solvents. The CHEM21 project has undertaken a survey of these guides to compile the data, analyse and understand the differences therein and have subsequently published a combined guide. [5] [6]
In this video, Helen Sneddon talks us through the general GSK solvent selection guide.[1]
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