In this video, Helen Sneddon describes guidance available for work-ups, chromatography and some specific types of reaction (amide formation and reductive amination).
Amgen have created a chromatography guide for selecting a solvent/eluent mix to replace DCM/MeOH mixtures [1].
Derived from a screened set of drug-like molecules with a range of differing functionalities and physicochemical parameters, the charts allow solvents mixtures with similar eluting strengths to be identified.
For further reading, the ACS GCI PR have published a highly recommended review article on sustainable chromatography. [2]
