Solvent Guides for Specific Applications


In this video Helen Sneddon describes guidance available for work-ups, chromatography and some specific types of reaction (amide formation and reductive amination).


Chromatography Guides

Amgen have created a chromatography guide for selecting a solvent/eluent mix to replace DCM/MeOH mixtures [1].  

Derived from a screened set of drug-like molecules with a range of differing functionalities and physicochemical parameters, the charts allow solvents mixtures with similar eluting strengths to be identified.

For further reading, the ACS GCI PR have published a highly recommended review article on sustainable chromatography [2]

  1. J. P. Taygerly, L. M. Miller, A. Yee and E. A. Peterson, A convenient guide to help select replacement solvents for dichloromethane in chromatography, Green Chem., 2012, 14, 3020-3025.
  2. E. A. Peterson, B. Dillon, I. Raheem, P. Richardson, D. Richter, R. Schmidt and H. F. Sneddon, Sustainable chromatography (an oxymoron?), Green Chem., 2014, 16, 4060-4075.