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ACS GCI Pharmaceutical Roundtable Selection Guides

Both Pfizer and GSK developed inhouse reagent selection guides to help their scientists make informed choices around reagent selection [1], [2]. The material was donated to the ACS GCIPR for expansion and development into searchable online guides for the transformations most commonly used for pharmaceutical discovery and development.

The ACS tool uses Venn diagrams to allow reagents to be selected according to greenness, utility and scalability.  For the reagents highlighted, scaled up examples of their use are included, along with key references relating to the reagent and a short commentary.

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  1. K. Alfonsi, J. Colberg, P. J. Dunn, T. Fevig, S. Jennings, T. A. Johnson, P. H. Kleine, C. Knight, M. A. Nagy, D. A. Perry and M. Stefaniak, Green chemistry tools to influence a medicinal chemistry and research chemistry based organisation, Green Chem., 2008, 10, 31-36.
  2. Joseph P. Adams,  Catherine M. Alder,  Ian Andrews,   Ann M. Bullion,   Matthew Campbell-Crawford,   Michael G. Darcy,   John D. Hayler,   Richard K. Henderson,   Catriona A. Oare,   Israil Pendrak,   Anikó M. Redman,  Leanna E. Shuster,   Helen F. Sneddon  and  Matthew D. Walker, Development of GSK’s reagent guides – embedding sustainability into reagent selection, Green Chem., 2013, 15, 1542.