In their survey of the reactions used by the pharmaceutical industry in the production of drug candidates, Carey et al. note that not a single catalytic method was used for the synthesis of amides. There is still a pressing need for scalable catalytic methodologies for the synthesis of amides that are atom efficient and avoid the production of waste; this has encouraged research into the efficient preparation of amide bonds.
Details on recent developments in the synthesis of amide bonds can be found in the following reviews:
A specialised review of metal‑catalysed approaches to amide bond formation:
Review of catalytic amide bond formation on non-activated amines and carboxylic acids: