C-F Bond Formation: Summary and Further Reading

Reproduced Content

This page reproduces content from G. Pattison, ‘Green’ and Sustainable Halogenation Processes, in Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, L. Summerton, H. F. Sneddon, L. C. Jones and J. H. Clark, Royal Society of Chemistry, Cambridge, UK, 2016, ch. 17, pp. 203-217.

It is copyright to the Royal Society of Chemistry (RSC) and is reproduced here with their express permission. If you wish to reproduce it elsewhere you must obtain similar permission from the RSC.

Advances are being made in ‘green’ and sustainable fluorination reactions; however, challenges still remain in the mild and selective halogenation of a range of systems. The widespread appearance of fluorine in pharmaceuticals and synthetic intermediates means it is vital that further progress is made in the development of convenient fluorination reactions with minimal environmental impact.

Recommended reading:

G. Pattison, ‘Green’ and Sustainable Halogenation Processes, in Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, The Royal Society of Chemistry, 2016, ch. 17, pp. 203-217.

A. Harsanyi and G. Sandford, Organofluorine chemistry: applications, sources and sustainability, Green Chem., 2014, 17, 2081–2086.

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