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Route Selection and Scale Up: Worksheets

In this exercise, you will contrast the medicinal chemistry and manufacturing routes to Lotrafiban and critically assess why the early route is suitable for medicinal chemistry but unsuitable for manufacturing. Details of the medicinal chemistry route and the manufacturing route are given in these briefing sheets:

In order to answer the questions fully, the following literature references should be read and analysed beforehand.  

Medicinal Chemistry route:

Manufacturing route (split into two parts):