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Background to Green Chemistry
Introduction to the Pharmaceutical Industry
Pharmaceutical Process Chemistry
Critical Elements
Renewable Resources
Solvents
Guides and Metrics
Solvent Selection Guides
Reagent Guides
Metrics
Solvents
Use of Solvents
Issues Surrounding Solvent Use
Solvent Guides
Solvent Recovery
Alternative Solvents
Telescoping
Solvents: Quiz
Solvents: Study Exercises
Solvents: Summary and Further Reading
Synthetic Toolbox
Route Selection
Base metal Catalysis
Biocatalysis
Multicomponent Reactions
C-H Activation
Carbonylation
C-F Bond Formation
Flow Chemistry
Amidation
Synthetic Biology
CHEM21 Publications
Process Design
Route Selection
GMP
Introduction to Process Engineering
Route Selection and Scale Up: Case Study and Exercise
Process Safety
Reactive Hazards in Scaling Up: Case Study and Exercise
Reaction Work-up and Product Isolation
Design of Experiments
Environmental Legislation
Abatement and Waste Treatment
Life Cycle Impacts
Examining the Life Cycle
The Fate of APIs
Benign by Design
Life Cycle Impacts: Summary and Further Reading
About
Contact
Home
Foundation
Background to Green Chemistry
Introduction to the Pharmaceutical Industry
Pharmaceutical Process Chemistry
Critical Elements
Renewable Resources
Solvents
Guides and Metrics
Solvent Selection Guides
Reagent Guides
Metrics
Solvents
Use of Solvents
Issues Surrounding Solvent Use
Solvent Guides
Solvent Recovery
Alternative Solvents
Telescoping
Solvents: Quiz
Solvents: Study Exercises
Solvents: Summary and Further Reading
Synthetic Toolbox
Route Selection
Base metal Catalysis
Biocatalysis
Multicomponent Reactions
C-H Activation
Carbonylation
C-F Bond Formation
Flow Chemistry
Amidation
Synthetic Biology
CHEM21 Publications
Process Design
Route Selection
GMP
Introduction to Process Engineering
Route Selection and Scale Up: Case Study and Exercise
Process Safety
Reactive Hazards in Scaling Up: Case Study and Exercise
Reaction Work-up and Product Isolation
Design of Experiments
Environmental Legislation
Abatement and Waste Treatment
Life Cycle Impacts
Examining the Life Cycle
The Fate of APIs
Benign by Design
Life Cycle Impacts: Summary and Further Reading
About
Contact
Home
Process Design
Process Safety
Process Safety: Quiz
Process Safety: Quiz
"
*
" indicates required fields
In the GHS system, which hazard statements refer to health hazards?
*
H2xx
H3xx
H4xx
Which of the following chemical groups are the three most unstable?
*
Ester RCOOR
Nitro RNO2
Peroxide ROOR
Olefin
Azide RN3
What is needed for a safe scale-up?
*
Equilibrated equations
A robust operating procedure
Theoretical knowledge of the reaction mechanism
A risk analysis
A reliable In-Process Control
The DSC graph of a reaction mixture shows a peak with a T(onset) at 150°C and a maximum at 190°C, with an energy of 560 J/g (exotherm). Which of these assumptions are true?
*
The reaction can be run safely at 40°C
The reaction can be run safely at 70°C
Acetone (BP: 56°C) cannot be used for this reaction
The reaction mixture is hazardous
The DSC graph of a reaction mixture shows a peak with a T(onset) at 150°C and a maximum at 190°C, with an energy of 560 J/g (exotherm). Which of these assumptions are true?
*
'BP'<'TD'<'MTSR'
'MTSR'<'TD'<'BP'
'TD<'BP'<'MTSR'
'MTSR'<'BP'<'TD'
'BP'<'MTSR'<'TD'
'TD'<'MTSR'<'BP'
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Route Selection
Recap of the SELECT Criteria
Application to API Synthesis
Route Selection: Self-assessment Question
Route Selection: Summary and Further Reading
GMP
GMP in the Pharmaceutical Industry
GMP: Self-assessment Questions
GMP: Summary and Further Reading
Introduction to Process Engineering
Why can’t we scale up directly?
Problems that can Occur During Scale-up of Catalytic Reactions: Part 1
Problems that can Occur During Scale-up of Catalytic Reactions: Part 2
Process Economics
Introduction to Process Engineering: Self-assessment question
Route Selection and Scale Up: Case Study and Exercise
Route Selection and Scale Up: Worksheets
Process Safety
Screening Experiments
Scaling Up
Reaction Calorimetry
Process Safety: Quiz
Reactive Hazards in Scaling Up: Case Study and Exercise
Reactive Hazards in Scaling Up: Worksheets
Further Analysis of the T2 Incident & Recommended Reading
Design of Experiments
Some Definitions
The Experimental Design Process
Comparing Traditional Approaches to Experimental Design
Examples of Variables and Responses for a Chemical Process
Main Effects and Interactions
Experimental Designs: Factorial Designs
Experimental Designs: Response Surface Design
Design of Experiments: Summary and Further Reading
Reaction Work-up and Product Isolation
Reaction vs DSP Examples
Work-up and Isolation Techniques
Telescoping
Example of Improved Work-up Process
Reaction Work-up and Product Isolation: Quiz
Reaction Work-up and Product Isolation: Summary and Further Reading
Environmental Legislation
Industrial Emissions Directive (IED)
Water Framework Directive (WFD)
Solvent Emissions Directive (SED)
Montreal Protocol
REACH
Non-governmental Organizations
Abatement and Waste Treatment
Why do we need abatement and waste disposal?
Air Emissions
Liquid Emissions
Solid Emissions
Abatement and Waste Treatment: Quiz
Abatement and Waste Treatment: Summary and Further Reading
