There are a range of different techniques that can be employed for reaction work-up and product, each with their own associated advantages and disadvantages. In this module, we have seen evidence to demonstrate that it is important to think holistically about a process as a whole and ensure that the impact of work-up/down stream processing is not ignored.
The ACS GCI PR have developed an Analytical Method Greenness Score (AMGS) Calculator which provides a metric to allow for comparison of separation methods used in drug development. This aims to encourage the selection of “greener” methods by providing an awareness of the environmental impact associated with given separation methods.
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