Reactive Hazards in Scaling Up: Case Study and Exercise
Safety is the highest priority of all the SELECT criteria, a reaction should never be scaled-up unless it’s safe to do so; the reaction hazards are understood and they can be controlled. Information on the investigation into chemical accidents can be found on the U.S. Chemical Safety Board website. A reactive chemical explosion that happened at T2 Laboratories Inc. is explored here as a case study to provide an insight into the role kinetics and thermodynamics play when scaling up a chemical process.
- Route Selection
- GMP
- Introduction to Process Engineering
- Route Selection and Scale Up: Case Study and Exercise
- Process Safety
- Reactive Hazards in Scaling Up: Case Study and Exercise
- Design of Experiments
- Some Definitions
- The Experimental Design Process
- Comparing Traditional Approaches to Experimental Design
- Examples of Variables and Responses for a Chemical Process
- Main Effects and Interactions
- Experimental Designs: Factorial Designs
- Experimental Designs: Response Surface Design
- Design of Experiments: Summary and Further Reading
- Reaction Work-up and Product Isolation
- Environmental Legislation
- Abatement and Waste Treatment